7th International Symposium on Antimicrobial Peptides AMP2021. Salle des souvenirs scientifiques, musée Pasteur, Institut Pasteur Paris. Deadline. Biotechnology: DNA polymerases that can replicate DNA without a primer! Researchers from Hong-Kong University - Pasteur Research Pole and Institut Pasteur of New Caledonia are winners of the "Pasteur Network Talent Award" 2020. Some 250 PhD students are present in campus laboratories in any one year, making the Institut Pasteur a major stakeholder when it comes to training young scientists through research. Calendar of symposium, seminars and others events View all. The Insitut Pasteur is addressing the major scientific and health issues facing the world today, The Institut Pasteur in 2018: A legacy of excellence. The following are offered at the Education Center or on the Institut Pasteur campus: The Institut Pasteur is internationally renowned for the quality of its teaching programs. Exploring the formation of distinct memories, Health and environment: Institut Pasteur and AFD commit to a new program, Hepatitis B may infect twice more African babies than HIV, Hepatitis B: natural controllers shed light on immunity mechanisms, Hepatitis B: new guidelines for treating HBV-positive pregnant women, High-level microscopy unveils bacteria’s adaptation mechanisms, How Chlamydia trachomatis hijacks energy stores from its host, How Helicobacter pylori survives gastric acidity, How Listeria monocytogenes blocks intestinal villus invasion. History. 09:00. Christophe Zimmer 17 Teams. El Instituto de Zoonosis Luis Pasteur es un establecimiento de salud pública que tiene como misión: “Entender en todo lo relacionado con el diagnóstico, prevención y control de las zoonosis urbanas en la Ciudad de Buenos Aires, a fin de preservar el buen estado de salud de la población humana y animal de la ciudad”. Call. May 2021. …) External Grants: Funding by the Institut Pasteur (and even additional funding by government agencies) is insufficient to maintain a unit or a group. Fermé en janvier 2000.Les deux pavillons de l'hôpital sont reliés par une serre classée "monument historique", vue du C.I.S. Providing open-access workstations unlock barriers to compute-intensive tools. CH-1700 Fribourg. What is the "tiger mosquito" (Aedes albopictus)? An Education Center at the forefront of scientific innovationThe Institut Pasteur’s Education Center has been part of the legacy of its founder, Louis Pasteur, since Émile Roux’s first "Technical Microbiology” course in 1889. Mid-career group leader position at Institut Pasteur – Chemical Biology. Computational Biology. Researchers from the Institut Pasteur in Iran and French Guiana Win the 2018 "Pasteur Talent" Award, Roka village in Cambodia: a history of iatrogenic HIV infection, Roman Thibeaux’s joust with bacterial armor, Six institutions members of the Institut Pasteur international network engaged in an international coalition against epidemics in Africa, Spencer Shorte appointed Chief Scientific Officer to Institut Pasteur Korea, Strong increase in antibiotic resistance in Cambodia, Successful second international medical entomology course in Vientiane, Laos, The 2019 "Prince Albert II of Monaco - Institut Pasteur" Prize is awarded to Joacim Rocklöv, The 49th Institut Pasteur International Network Directors council will be held in Abidjan, The Chinese Ambassador to France visits the Institut Pasteur, The FioCruz-Pasteur-USP tripartite agreement is bearing fruits, The Institut Pasteur International Network enters the GloPID-R alliance, The Institut Pasteur International Network pays tribute to Professor Ogobara Doumbo, The Institut Pasteur de Guinée opens its first laboratory in Conakry, The Institut Pasteur de Nouvelle-Calédonie describes 12 new species of leptospires and pays tribute to Pasteurians, The Institut Pasteur in French Guiana confirms a case of yellow fever, The Institut Pasteur launches a Scientific Platform in the university of São Paulo Research and Innovation Center, The first "Pasteur International Talent" reward two young scientists of the Institut Pasteur in Guadeloupe and Montevideo, The medical entomology course at the Institut Pasteur celebrates its 30th anniversary, Three projects from the Institut Pasteur in Dakar and Madagascar selected for funding by AESA’s Grand Challenge Africa, Twelve new species of Leptospira discovered in New Caledonian soils, Unprecedented solidarity and support to accompany the member institutes of the International Network in the face of the COVID-19 pandemic, Viral hepatitis: the challenge of communication in Africa, Zika virus in the Pacific : the influence of the geographical context on an outbreak’s emergence, The Institut Pasteur International Network, Institut Pasteur International Network Missions, Organization of the institut pasteur international network, Institut Pasteur international network's reports, The use of animals in the Institut Pasteur's research programs, Center for Animal Resources and Research (C2RA), Center for Technological Resources and Research (C2RT), The Center of Bioinformatics, Biostatistics and Integrative Biology (C3BI), Brain connectivity and neurodegenerative diseases, Cancer Initiative at the Institut Pasteur, New diagnostic approaches and innovative therapies, Infectious diseases emergence and transmission dynamics, Novel approaches to diagnosis, vaccination and therapy (12 entities), Pathogen genomics and microbiota (8 entities), Vector-pathogen interactions (4 entities), Meet health challenges of the 21st century, Vaccinology and Immunotherapy Initiative: Clinical Research, Vaccinology and Immunotherapy Initiative: Fundamental Research, Vaccinology and Immunotherapy Initiative: Innovation – Vaccine Candidates, Legacies, notarized donations and life insurance policies, Alzheimer's and Parkinson's – the current state of research, Alzheimer’s disease: towards new diagnostic and therapeutic tracks, Autism: a unique event at the Institut Pasteur, Autoimmune diseases: When our own defenses turn against us, Cholera: researchers track the origin of epidemics in Europe since 1970, Coronavirus SARS-CoV-2: A look back at three months of mobilisation against an emerging disease (COVID-19), Ebola 2013-2016: lessons learned and how to respond to new epidemics, Ebola, plague, cholera, SARS… Emerging pathogens, an unpredictable threat, French Bioethics Law: an original participatory approach for the National Bioethics Consultation, How big data is revolutionizing health research, Human evolutionary genetics: the benefits of genetic diversity, Joining forces against the plague in Madagascar, Meningitis – the Institut Pasteur pledges its support to the "Ensemble contre les méningites" association, Microscopes – observe the living to fight disease, Salmonella outbreak: Institut Pasteur raises the alarm, Southeast Asia faces the rise of emerging diseases. Olivier Dussurget. Le lien vers cette page a été envoyé avec succès aux destinataires. Évènement Navigation You are here > u-paris.fr > Institut Pasteuru-paris.fr > Institut Pasteur. François Schweisguth 10 Teams. Marc Lecuit 8 Teams. Diphtheria: identification of a penicillin resistance gene, Discovery of a mechanism responsible for chronic inflammation in patients suffering from multiple sclerosis, Discovery of a restriction factor for hepatitis B virus, Discovery of new strains of the HTLV-4 virus in hunters bitten by gorillas in Gabon, Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes, Distinguishing resistence from resilience to prolong antibiotic potency, Division – a key moment in establishing cell polarity, Drastic reduction of exposure to malaria in Senegal, EDF Group Foundation supports the Institut Pasteur and the DIVA project, ERC grants: scientific excellence supported by Europe, Ebola: the answers to your questions in our disease sheet, Economist Jim O’Neill, and other experts, discuss Antimicrobial Resistance at the Institut Pasteur, Effect of the seasons on pneumococcal infections, Efficacy of cancer treatment: two bacteria in the microbiota identified, Embryonic development – the role of Nodal in establishing cardiac asymmetry, Esrrb transcription factor plays a key role in maintaining stem cell identity even after countless divisions, Establishment of the Hearing Institute, a new Institut Pasteur center: scientific experts within the field of hearing brought together for a high-level international meeting, Exhibition in honor of Jules Bordet at the Université libre de Bruxelles. 26. EMBED. El Instituto Pasteur de París es una fundación francesa sin fines de lucro cuya misión es contribuir a la prevención y el tratamiento de las enfermedades, especialmente las infecciosas, a través de la investigación, la enseñanza y acciones de salud pública. University of Fribourg. Alphonse Laveran (1845-1922) André Lwoff (1902-1994) Charles Nicolle (1866-1936) Daniel Bovet (1907-1992) François Jacob (1920-2013) Françoise Barré-Sinoussi, born in 1947; Ilya Mechnikov, Elie Metchnikoff in French (1845-1916) Jacques Monod (1910-1976) Jules Bordet (1870-1961) Luc Montagnier, born in 1932 With its new "Omics" buildings, the Institut Pasteur continues its digital revolution, Yellow fever: a new method for testing vaccine safety, Zika: an accurate estimation of the neurological risks in unborn children, Zika: silent long-term circulation in Thailand, All SARS-CoV-2 / COVID-19 from the Institut Pasteur, A SARS-CoV-2 genome sequencing technique to analyze low-quality clinical samples, A combination of cutting-edge proteomic approaches for improving understanding of SARS-CoV-2 infection mechanisms, A technique to identify key cellular factors for SARS-CoV-2 infection, A zebrafish model to study SARS-CoV-2 neuroinvasion, Accelerating the identification & design of SARS-CoV2 antiviral drugs in combination with the “DrugDesign_SARS2” project, Antibody profiling in recovering patients and development of a serological test for an epidemiological survey in individuals exposed to SARS-CoV-2, Building a collection of human biological samples in France, Characterization of interaction between SARS-CoV-2 Nsp3 protein and non-canonical nucleic acid structures (G4) present in infected cells, Characterization of variable systemic and mucosal immunity during SARS-CoV-2 infection and recovery, Covid-19 risk evaluation among the household contacts of the first cases in Africa, Covid-19: A vaccine candidate using a lentiviral vector, Covid-19: vaccine against SARS-CoV-2 infection, using the measles vector, Deciphering the virus interactions with the entry receptors in human cells, and their potential inhibition, Defective viral genomes (DVGs), potential antiviral inhibitors of SARS-CoV-2, Descriptive study: epidemiological, clinical and immunological analysis of SARS-CoV-2 cases in the Metropolitan Region of São Paulo, Brazil, Developing a rapid diagnostic test to detect SARS-CoV2 virus in various environment, Development of an animal model and accelerated development of a DNA vaccine candidate, Development of novel nano-based multi-epitope vaccine against coronavirus SARS-CoV-2 - Generation of Humanized NSG transfer mouse model for vaccine testingAim: We hypothesize that it may be possible to generate protective anti-SARS-CoV-2 immuneresponse in, Development of simple Covid-19 serological tools and targeted serosurvey of at-risk individuals, Drug Repurposing & Design to inhibit the SARS-CoV2 proteases, Engineering an ACE2 derived polypeptide for label-free, real-time detection on a smartphone device and therapeutic intervention, Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia, Evaluation of SARS-CoV-2 infection spread in various populations groups in Cameroon, Evaluation of clinical presentation and evolution of SARS -CoV-2 coronavirus infection in Senegal, Evolution of SARS-CoV-2 and the antibody immune response in humans during infection, Find potent antiviral drugs against SARS-CoV2 by targeting well identified proteins essential to the viral cycle, Generation of animal models sensitive to SARS-CoV-2 to test vaccines or drugs, Household transmission investigation study for SARS in overseas territories, Identification and isolation of potent human neutralizing antibodies against SARS-CoV-2, Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection, Investigating the role of apico-basal proteins during SARS-Cov2 infection, Investigation of the first cases of coronavirus (COVID-19) infections and their contacts in Antananarivo, Madagascar, Isolating and characterizing the human antibodies that neutralize SARS-CoV-2, Mechanisms of intercellular spreading of SARS-CoV-2: assessing the role of TNTs to escape immune surveillance and expand tropism and pathogenicity, Modeling human SARS-CoV-2 infection in mice with human lung xenografts, Monitoring the origins and transmission/spread of SARS-CoV-2 in Laos and Vietnam: searching for SARS-like viruses and detecting antibodies in vertebrates, Neurological implications of SARS-COV-2 infection – a transversal study, Nicotinic modulation of SARS-CoV-2 infection in the brain, Origins, natural reservoirs and interspecies transmission of SARS-CoV-2 and other SARS-like coronaviruses, Production of recombinant antigens from two SARS-CoV-2 proteins and generation of nano-antibodies against these proteins for diagnostic and therapeutic applications, Profiling SARS-CoV-2 intra-viral and virus-host interactions on the basis of innate immunity signaling, Protocol for assessment of potential risk factors for 2019-novel coronavirus (2019-nCoV) infection among health care workers in a health care setting, Randomized trial of Covid-19 chemoprophylaxis in healthcare professionals, Red Cross health workers and volunteers and continuity of care with COVID-19: an operational approach using mixed methods, Restriction of SARS-CoV-2 replication by coding and non-coding genes, SARS-CoV-2 fusion, replication and host responses, Sequence the complete genome of Covid-19 directly and at low cost from prepared RNA samples from patients, Serological surveillance of SARS-CoV-2 and seasonal coronaviruses, Short Amplicon Based Sequencing Of SARS-CoV-2 for low-input samples, Spike glycoprotein, lentiviral vectors and B/T-cell vaccine, The use of Artificial Intelligence Methods to Discriminate Covid-19 from other Community Acquired Pneumopathy using Chest X-Ray and CT images, Urgent Discovery of Drug Candidates That Target Coronavirus SARS-CoV-2, Working towards controlled detection of SARS-CoV-2 by the innate immune system, rBCG vaccine secreting SARS-CoV-2 antigens, Global Health at the Human-Animal-Ecosystem Interface, MOOC Concepts and Methods in Epidemiology - Institut Pasteur/Cnam, MOOC Diagnosis and prognosis biomarkers in global health - Institut Pasteur, MOOC In the footsteps of Zika… approaching the unknown​, Mooc From neuron to behavior - Institut Pasteur/Cnam, The Institut Pasteur Online Diploma of Infectious Diseases (DNM2IP), Erasmus+ University of Szeged, Faculty of Medicine, University of Szeged, Faculty of Medicine, Pasteur-Paris University International doctoral program​ (PPU), 4-year research group within the Scientific Platform Pasteur-University of Sao Paulo, Groupes à 4 ans à l'Institut Pasteur de Shanghai - Académie des Sciences de Chine, Cité Internationale Universitaire de Paris, MOOC Medical entomology - Insect vectors and transmission of pathogens, New Edition Of The Free On-Line Mooc Malaria, New Edition Of The Free On-Line Mooc Tuberculosis, New Free On-Line Course Created By Institut Pasteur: Clinical Trials In Infectious And TropicalL Diseases, Registration for Pasteur/Cnam School of Public Health, Registration open for the Institut Pasteur neuroscience MOOC​, Pasteur International Network association, 1st workshop on Translational Venomic Medecine, Infectious diseases pathogenesis in Asia/Pacific, Insects and vector-borne diseases in Amazonia and the Caribbean: from field to lab, Methodology of Clinical Trials and Practical Implementation, Persistent Viral Infections and Immune evasion, Workshop on Surveillance and Control of Rabies, Centre de ressources biologiques de l’Institut Pasteur (CRBIP), Clinical Investigation and Access to BioResources (ICAReB), Collection Nationale de Cultures de Microorganismes (CNCM), Detection, Financing of Innovation and Entrepreneurship Office, Industrial Agreements - Post Contract and Strategic Alliance, Technology Transfer and Industrial Partnership, the Institut Pasteur International Network. Departments. Institut Pasteur | 85,510 followers on LinkedIn. 12 Jan 2021. conference. En este periodo, ha contribuido con descubrimientos que han permitido a la medicina controlar enfermedades virulentas como la Difteria, el Tétano, la Tuberculosis, la Poliomielitis, la Gripe y la Fiebre amarilla, y fue el primer laboratorio que logró aislar el HIV, que provoca el Sida. Finally, some specialized tools require special deployment efforts, e.g. Yellow fever, the story of a re-emerging virus. Hôpital spécialisé dans les maladies infectieuses et immunitaires. How human pathogens may emerge from the environment, How investigating the population biology of Listeria is ushering in a new era in listeriosis surveillance​, How the influenza virus achieves efficient viral RNA replication, Human contact plays big role in spread of some hospital infections, but not others, Icypro, an advanced bioimage analysis platform for health technology professionals, Identification of a new bacterial defense system against phages, IgG antibodies activate blood platelets and contribute to the severity of anaphylaxis, Immature heart cells persist in the adult heart and react to infarction, Immune cells fighting blood cancer visualized for the first time, In France, Aedes albopictus better transmits the African "Zika" than the Asian one, In the Pasteur library with Hervé Di Rosa, Inauguration of the Hearing Institute, an Institut Pasteur center, Infant nutrition: an overly rich diet may increase susceptibility to inflammatory diseases, Infravec2 new insect vector research tools: no-cost resources for scientists fighting mosquito-transmitted diseases, Innate immune responses – redefining how innate lymphoid cells develop, Insect vectors: a mosquito capable of limiting viral infection, Insecticide resistance genes affect vector competence for West Nile virus, Institut Pasteur in Guinea: One Health training to strengthen local expertise, Institut Pasteur scientist Mélanie Hamon wins the 15th Georges, Jacques and Elias Canetti Prize, Institut Pasteur scientists during the Great War, Institut Pasteur team identifies a key protein linked to ageing, Interview with Prof. Jean-François Delfraissy about French National Bioethics Consultation, a forum for the public and the research community, Just the two of us: Holding hands can ease pain, sync brainwaves, Key cellular factors for chikungunya virus replication identified, Launch of the recruitment process for the Director of the Institut Pasteur, Leishmaniasis: epigenetic mechanisms implicated in infection, Leptospirosis: elucidation of a new gene regulation mechanism based on DNA modification, Listeriosis: food type determines Listeria monocytogenes virulence, Long-awaited determination of the 3D structure of a human transporter, Low competence of Aedes mosquitoes for Zika virus transmission, LuLISA project, bioluminescence as a tool for human diagnostics, from allergy to Covid19, Lyme disease – chipmunks may affect tick infection but the risk of transmission is more complex, Lyme disease: a study on the speed of transmission by infected ticks, Mechanism of activation of a major toxin involved in whooping cough, Meningitis: analysis of the long-term protection of the MenAfriVac vaccine, Meningococcal infection: bacterial aggregates form a thick honey-like liquid that flows through blood vessels, Meningococcus and COVID-19: fewer cases of meningitis but higher incidence of pneumonia observed during the lockdown in early 2020, Microbiota and solid food introduction: interview with Gérard Eberl, Modeling to monitor and anticipate the Zika outbreak in Martinique, Monkeypox: the epidemic potential will continue increasing, with diminishing herd immunity against viruses responsible for smallpox, MosKeyTool: a free and interactive tool to identify mosquitoes of the Euro-Mediterranean region, Multiscale structure of the Escherichia coli genome, Natural molecules to stimulate human antimicrobial defenses, Neurobiologist Jean-Pierre Changeux tells us the story of the nicotinic acetylcholine receptor, Neurodegenerative diseases: recycling mechanisms open up new avenues for therapy, Neurodevelopmental disorders: a daily practical guide by InovAND to help families deal with the difficulties of lockdown, Neurological impact of the Zika virus finally exposed, New Fellowships have been announced to enhance the next generation of global health leaders, New insight into body's response to killer fungus, Novel coronavirus (SARS-CoV-2): what we know about the disease, Novel neurotropic arbovirus identified in France: the Umbre virus, Olivier Gascuel: Inria – French Académie des sciences Grand Prize, Omics: Biology in the digital age at the Institut Pasteur, Parkinson's: new discoveries about nanotubes, transporters of toxic proteins, Pasteur iGEM 2019: simplified diagnosis of bacterial infections, Pasteur's Nephew – Or the Adventurous Life of Adrien Loir, Scholar and Globe-Trotter, Pasteurdon 2019: Graffitti artists meet scientists and create stunning lab coats, Phage therapy effective in Crohn's disease, Phagotherapy: a support for the work on bacteriophages of a Franco-American team (Institut Pasteur and Georgia Tech), Phylogenetic analysis of SARS-CoV-2: strengths, limitations and over-interpretations, Plague outbreak: advice for travelers to Madagascar, Pneumococcal infections: KDM6B, a key epigenetic regulator in the cellular response, Presbycusis: ultra-rare genetic mutations responsible for a quarter of cases occurring around the age of 50, Progress in the understanding of the mechanisms of genetic diversification in a major fungal pathogen of humans, Candida albicans, Proof-of-concept study reveals feasibility of eliminating rabies in Africa, Rabies: new prophylactic and therapeutic avenues, Regulation of metabolic pathways: lessons from an intracellular bacterium, Regulation of muscle stem cells in their niche: juggling external and internal cues, Report on the 2018 Pasteur Vallery-Radot Prize, Réseau Bactériophages France receives the François Sommer Foundation scientific prize, S3ODEON 2019 – Institut Pasteur partner to an event linking science and society, SODA, a new analysis tool for fluorescence imaging, Severe inflammation: clues towards a therapeutic approach using immune memory, Sex-based differences influence chronicity in urinary tract infections, Shedding light on almost indestructible archaeal pili, Shedding light on the burden of dengue in Bangladesh, Sign up for the upcoming Institut Pasteur MOOCs, Sleeping sickness: one step further in improving diagnosis, Small intestine regulates immune surveillance of colorectal cancer during chemotherapy treatment, Staphylococcus aureus: a new mechanism involved in virulence and antibiotic resistance, Study reveals conditions for the onset of severe forms of COVID-19, Studying synaptic protein assemblies helps us understand the nature of communication between neurons, Success of the 2019 Z Event in aid of the Institut Pasteur, Summer University dedicated to the creation of life sciences company, Support for government policy for the prevention of infectious diseases, Ten years ago, Françoise Barré-Sinoussi and Luc Montagnier won the Nobel Prize in Medicine, The 2017 Pasteur iGEM team – a purifying and recycling device, The 2018 Institut Pasteur Annual Report is available, The BTP PLUS Foundation is funding a research project to fight asbestos cancer, The Ebola virus adapted to better infect humans during the 2013-2016 epidemic, The French Parliamentary Office of Science and Technology pays a visit to the Institut Pasteur, The ISG15 protein plays a key role in fighting bacterial infections, The Institut Pasteur in Côte d'Ivoire diagnoses a dengue epidemic in Abidjan, The Institut Pasteur wishes you a happy new year 2020, The Institut Pasteur wishes you all the best for 2021, The Institut Pasteur: a leader in the fight against antibiotic resistance, The Musée Pasteur featured in book of Parisian hidden gems, The Zika virus modifies the morphology of the cells and makes them implode, The book “Institut Pasteur: Today's Research, Tomorrow's Medicine” available in US bookstores, The documentary Unseen Enemy in streaming on ARTE.TV, The factors that most affect our immune system, The first "3D" metagenomics experiment on a complex natural microbiome, The first case of prolonged remission in an HIV-infected child – an interview with Asier Saez-Cirion, The hidden population of multidrug-resistant Klebsiella bacteria colonizing the human digestive tract, The issues of epidemiology with Arnaud Fontanet, The molecular crossbow: a vital weapon in the bacterial arsenal, The shape of the heart as explained by Audrey Desgrange, The structure and assembly of the Enterohemorrhagic Escherichia coli type 4 pilus deciphered, The tiger mosquito returns to France: 51 départements on red alert, The web meets genomics: a DNA search engine for microbes, Third type of membrane envelope in a hyperthermophilic virus, This week, France Culture's flagship documentary series explores the life and work of Louis Pasteur, Tiger mosquito in France: 58 départements on red alert, Tiger mosquitoes: heightened surveillance in France, from May to November 2018, Titan Krios (TM): inauguration of the world’s most powerful microscope at the Institut Pasteur, Tribute to the Institut Pasteur in Genes & Immunity, Tumor cells eliminating their neighbors using a newly discovered mechanism, Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes, Two major types of rabies that evolved in different ways, Unmasking an ancestral mechanism of integrons — key players in antibiotic resistance, Unseen Enemy, a film about our vulnerability to global epidemics, Urinary tract infections: the mechanisms behind the lack of immune memory in many patients, Use of the maladiecoronavirus.fr web application during the first wave helped reduce call volumes to the French medical emergency number, Usher syndrome type III: cochlear gene therapy preserves hair cell synaptic transmission to the auditory neurons, Using medicinal chemistry to improve diagnostic methods, Viral sequence integrated in mosquito genome controls infection by related virus.

Azize Diabate Instagram, Henri Cartier-bresson Essai, Test Covid Orly, Institut Pasteur Email, Tatouage Lune Fleur, Ici Tout Commence Du 12 Janvier 2021, Antigone Sophocle Résumé Acte Par Acte, Arthur, Un Amour De Milliardaire Streaming, Loyalty En Arabe, Auto-évaluation Ou Autoévaluation Orthographe,